(±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylhydantoin, (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylimididazolidine-2,4-dione
5-ethyl-5-(4-hydroxyphenyl)-3-methylimidazolidine-2,4-dione
CAS: 61837-65-8
Molecular Formula: C12H14N2O3
(±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylhydantoin, (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylimididazolidine-2,4-dione - Names and Identifiers
| Name | 5-ethyl-5-(4-hydroxyphenyl)-3-methylimidazolidine-2,4-dione |
| Synonyms | 4'-Hydroxymephenitoyn 5-Ethyl-5-(4-hydroxyphenyl)-3-Methyl- 5-Ethyl-3-methyl-5-(4-hydroxyphenyl)hydantoin 4-Hydroxy-5-ethyl-3-methyl-5-phenylimidazolidin-2-one 5-ethyl-5-(4-hydroxyphenyl)-3-methylimidazolidine-2,4-dione 5-Ethyl-3-methyl-5-(4-hydroxyphenyl)imidazolidine-2,4-dione 5-(p-Hydroxyphenyl)-3-methyl-5-ethyl-imidazolidine-2,4-dione (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylhydantoin, (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylimididazolidine-2,4-dione |
| CAS | 61837-65-8 |
| InChI | InChI=1/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17) |
(±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylhydantoin, (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylimididazolidine-2,4-dione - Physico-chemical Properties
| Molecular Formula | C12H14N2O3 |
| Molar Mass | 234.25 |
| Density | 1.249±0.06 g/cm3(Predicted) |
| Melting Point | 153-154°C |
| Solubility | DMSO: >5mg/mL |
| Appearance | Solid |
| Color | white |
| pKa | 8.31±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.567 |
| In vitro study | 4-Hydroxymephenytoin is a metabolism of mephenytoin, which is an antiepileptic drug, and used as a CYP2C19 substrate. 4-Hydroxymephenytoin (4'-Hydroxymephenytoin) is used for developing UltraPerformance LC (UPLC) tandem mass spectrometry assays for evaluating CYP probe drugs and their relevant metabolites in human urine or plasma samples. |
(±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylhydantoin, (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylimididazolidine-2,4-dione - Risk and Safety
| WGK Germany | 3 |
(±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylhydantoin, (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylimididazolidine-2,4-dione - Reference Information
| biological activity | 4-hydroxymephentoin is a metabolite of the antiepileptic drug mephentoin; Mephentoin is a ligand of CYP2C19. |
Last Update：2024-04-09 21:01:54
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